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Serotonin hydrochloride
CAS No. 153-98-0
Serotonin hydrochloride( 5-HT | 5-Hydroxytryptamine )
Catalog No. M12176 CAS No. 153-98-0
Serotonin hydrochloride is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 27 | In Stock |
|
| 50MG | 38 | In Stock |
|
| 100MG | 47 | In Stock |
|
| 200MG | 65 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSerotonin hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionSerotonin hydrochloride is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
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DescriptionSerotonin hydrochloride is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.(In Vitro):Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki=?44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT.(In Vivo):Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis.
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In VitroSerotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki=?44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT.
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In VivoSerotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis.
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Synonyms5-HT | 5-Hydroxytryptamine
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number153-98-0
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Formula Weight212.68
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Molecular FormulaC10H12N2O·HCl
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Purity>98% (HPLC)
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SolubilityEthanol: 2 mg/mL (9.4 mM); Water: 43 mg/mL (202.18 mM); DMSO: 43 mg/mL (202.18 mM)
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SMILESCl.NCCC1=CNC2=C1C=C(O)C=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lamichhane K, et al. Ecotoxicol Environ Saf. 2014 Mar;101:124-30.
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